|
10-
Spectrophotometric Studies of the Oxidative Degradation of Paracetamol
Anwar S
El-Shahawy, Seddique M Ahmed, and Nager Kh Sayed
Chemistry Department, Faculty of Science, Assiut University, Assiut,
71516, Egypt,
*Correspondence to: S M
Ahmed; e-mail:
sm_ahmed@yahoo.com
Abstract
Oxidative degradation of paracetamol (PA) molecule was studied
using spectrophotometric technique. The oxidation constant (Kox)
of PA in the presence of different acids were determined. It was found
that the Kox is highly dependent on the
concentration and strength of the acid.
MNDO/3 calculations of the bond-order of PA showed that the
lowest bond order for N-C14 in the neutral or the cationic forms of
the PA molecule. These calculations indicate that the cleavage between
N and C14 is the first stage to form acetic acid. The limit of
detection can be as low as 0.755 ppm (mg L-1) of PA. This
is sensitive about two or four hundred times greater than the reported
previously kinetic parameters for the oxidation of PA in strong acidic
medium were computed. A good linearity (r = 0.9786) between the energy
consumed during the oxidation of PA against concentration of PA at
constant oxidant was obtained.. Activation parameters for the
oxidation process of PA have been computed and discussed.
Keywords:
Paracetamol,
oxidative degradation, activation parameters, MNDO/3 calculations.
<<< |
