4- Synthesis of m-(Substituted Aminohydroxypropoxy)phenylethanol-amines as Potential Biodynamic Agents.

Surat Kumar^* and Shri Nivas Rastogi^#

^*Department of Applied Sciences, Faculty of Engineering, Dayalbagh Educational Institute, Dayalbagh,

Agra-282 005 India; Email: kumar.surat@gmail.com

 ^# Medicinal Chemistry Division, Central Drug Research Institute, Lucknow-226 001 India

^*Author to whom correspondence may be addressed.

Abstract                                                         

Aryoxypropanolamines and aryethanolamines are prepared and used as b–adrenergic receptor blockers in the treatment of hypertension. In this report, we have incorporated the features of both of these kinds of b–adrenergic blockers in the lead structure and prepared these compounds using a novel bis-epoxide. This bis-epopxide was treated to generate m-(substituted aminohydroxypropoxy)phenylethanolamines. These compounds exhibited some promising stimulant and depressant activities.

 Key words: Aryoxypropanolamines, aryethanolamines, bis-epoxide, β-adrenergic blockers, β-adrenergic receptor antagonists

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