4. Novel Mixed Ligands Bi(V) Complexes with  12-((1R)-2, 2-dichloro-1-(1, 3-dihydroxy-1-(4-nitrophenyl)propan-2-ylamino)-1-hydroxyethoxy)-3, 6, 10, 12a-tetrahydroxy-4-isopropyl-6-methyl-1,11-dioxo-1, 2, 5a, 6, 11, 11a, 12, 12a-octahydrotetracene-2-carboxamide and 1-(4-(2,2-dichloro-1-(1, 3-dihydroxy-1-(4-nitrophenyl)propan-2-ylamino)-1-hydroxyethoxy)-2-(4-(3,5-dihydroxy-6-(hydroxymethyl)-4 (methylamino)tetrahydro-2H-pyran-2-yloxy)-5-formyl-5-hydroxy methyltetrahydrofuran-3-yloxy)-3,-dihydroxy-5-(methylamino)cyclohexyl)guanidine

Parashuram Mishra
Department of Chemistry,University of Delhi, Delhi-110007,India

Abstract: Novel mixed ligands 12-((1R)-2, 2-dichloro-1-(1, 3-dihydroxy-1-(4-nitrophenyl)propan-2-ylamino)-1-hydroxyethoxy)-3, 6, 10, 12a-tetrahydroxy-4-isopropyl-6-methyl-1,11-dioxo-1, 2, 5a, 6, 11, 11a, 12, 12a-octahydrotetracene-2-carboxamide and 1-(4-(2,2-dichloro-1-(1, 3-dihydroxy-1-(4-nitrophenyl)propan-2-ylamino)-1-hydroxyethoxy)-2-(4-(3,5-dihydroxy-6-(hydroxymethyl)-4(methylamino) -      -tetrahydro-2H-pyran-2-yloxy)-5-formyl-5-hydroxy methyltetrahydrofuran-3-yloxy)-3,-dihydroxy-5-(methylamino) cyclohexyl)guanidine have been synthesized by the reaction of chloramphenicol, tetracycline and streptomycin in an equimolar ratio in aqueous methanolic solutionligands. Ligands and their complexes have been characterized by elemental analysis, spectral [UV, IR 1HNMR and XRPD studies. The optimized structure of the complexes carried out by Chem Office software programme.

 Keywords: Antibiotics, tetracycline,  chloramphenicol, streptomycin, molecular modeling

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