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10.
Synthesis and antiinflamatory activity of bis(diacetylmonoxime)
thiocarbohydrazone and its Cu(II) complex
Ahmed A. El-Asmy*1, Yousery E. Sherif1 and G.A.
Al-Hazmi2
1Chemistry
Department, Faculty of Science, Mansoura University, Mansoura, Egypt
2Chemistry Department, Faculty of Science, Taiz
University, Taiz, Yemen
Corresponding author: E. mail:
aelasmy@yahoo.com
Abstract:
Some
thiosemicarbazones and bis(diacetylmonoxime) thicarbohydrazone
have been prepared, characterized and predicted through
quantitative structure activity relationship (QSAR) to show
their inhibition of cyclooxygenase-2-enzyme (COX-2).
Bis(diacetylmonoxime) thicarbo-hydrazone [H3DMT] was
found more analgesic and ulceroggenic. The descriptors are
mainly derived from molecular orbital calculations by the
semiemperical AM1 method. The inhibition activity was found to
depend on polarizability of the molecule. The study herein is
focused on testing the inflammatory activity of Cu(II) acetate,
H3DMT and [Cu2(HDMT)2(H2O)]
using collagen–adjuvant arthritis model in rats. The observed
anti-inflammatory of H3DMT and [Cu2(HDMT)2(H2O)]
makes an importance for future profiting due to their ability to
COX-2 inhibition and the high metal legibility.
Key words: Bis(diacetylmonoxime) thicarbohydrazone; Complexes;
Anti-inflammation
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