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3.
Biheterocyclic Ligands; Synthesis, Characterization and Coordinating
Properties of Bis (3-amino-4-oxo-3H-quinazolin-2-yl) alkanes with
Transition Metal Ions and Their Thermokinetic and Biological
Properties
Hussein M.
Al-Maydama*, Taj Edin Y. Al-Ansi, Yasmin M. Jamil and Ahmad H. Ali
Chemistry Deparment, Faculty of Science, Sana'a University
* Correspondence Auther: E-mail: hmaydama@yahoo.com;
P.O. Box 12286 Sana'a Republic of Yemen
Abstract:
The Co(II), Ni(II) and Cu(II) metal ions
complexes of Bis (3-amino-4-oxo-3H-quinazolin-2-yl) alkanes
(BAQs) have been prepared and characterized by elemental
analysis, molar conductance, infrared, magnetic susceptibility,
the electronic spectral data and thermal studies. Based on
spectral and magnetic results, the ligands are tetradentate
coordinating through the N and O-atoms of BAQs; six-coordinated
octahedral or distorted octahedral and some times
four-coordinated square planar or high spin five coordinated
structures were proposed for these complexes. Activation
energies computed for the thermal decomposition steps were
compared. The ligands and their metal complexes were tested in
vitro using filter paper disc method for their biological
effects. Their activities against two gram-positive, two
gram-negative bacteria and two fungal species were found to vary
from moderate to very strong.
Keywords: Biheterocyclic Ligands; Co(II), Ni(II) and Cu(II)
complexes; Synthesis; Characterization; Thermal Degradation;
Kinetic Parameters; Antimicrobial Activities.
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