Abstract: From the root wood of Artocarpus dadah which is grown in Lampung Province, Indonesia, a derivative compound of stilbene, oxyresveratrol has successfully been isolated. The structure of this compound was identified and determined based on the physical properties and spectroscopy techniques. The compound isolated was found to have high cytotoxicity against leukemia P-388 cancer cell and has high bioactivity against Bacillus subtillis, Escherichia coli, Rhizopus oligosporus, and Fusarium oxysporum.

One new coumarin and one known calaustralin have been isolated from the stem bark of Calophyllum incrasaptum M.R Henderson & Wyatt-Smith (Guttiferae). The structures of these compounds were established by means of spectroscopic analysis, including extensive 2D NMR studies. Most of the isolated compounds were tested in vitro against P388, L1210, murine leukemia cell lines, Yashida Sarcoma and Hela human cancer cell lines. The new coumarin 1 (its trivial name azizcoumarin) was cytotoxic against Yashida sarcoma, L1210, and HeLa cell lines (IC50 = 4.12; 5.35 and 6.57 µg/mL) respectively, but was not cytotoxic against P388 ((IC50 > 100 µg/mL).

 Key words: A dadah, oxyresveratrol, bioactivity, leukemia P-388 cancer cell.