Abstract: Several 1, 2, 4-triazolothiadiazines were prepared from 4-amino-5-mercapto-3-aryl-1, 2, 4-triazoles as possible antifungal agents. All the synthesized compounds were characterized by IR, PMR, MS spectral and elemental analyses. All synthesized compounds have been assayed for their antifungal activity against P. oryzae, B. cinerea, A. nigar, C. albicans and T. rubrum. All these compounds seem to have potential as precursors for the synthesis of triazole structures with diverse antifungal activities. Compounds containing aryl substituents at position three and the 1, 2, 4- triazole moiety at position one or two showed reasonable antifungal activities.


KEY WORDS:  Isonicotinic acid hydrazide, hydrazine hydrate, 1, 2, 4-triazoles, antifungal activity.