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4. Synthesis
of substituted cinnoline sulphonamide derivatives as anti microbial
agents
C.
Menezes *a, D. Satyanarayanab
Dept. of chemistry. Shree Devi College of Pharmacy, Mangalore,
India.
Dept. of chemistry. NGSM Institute of Pharmaceutical Sciences,
Mangalore, India.
Address of laboratory where work was carried out: Dept. of
Chemistry. NGSM Institute of Pharmaceutical Sciences. Deralakatte.
Mangalore India.
Author for correspondence: Mrs. Cylma Menezes. Dept. of Chemistry.
Shree Devi College of Pharmacy. Airport road, Kenjar. Mangalore
574142
India.
Email id:
cylmar@rediffmail.com
Abstract: A series of
substituted p-amino phenyl
sulphonamide-cinnoline-3-carboxamide were synthesized and
evaluated for anti-microbial activity. Several such
compounds showed good anti-microbial activity on comparison
to standard drugs Norfloxacin and Griseofulvin. Among them
6-iodo-4-(p-amino phenyl sulphonamide) cinnoline
-3-carboxamide, 7-fluoro-4-(p-amino phenyl sulphonamide)
cinnoline-3-carboxamide and 8-iodo-4-(p-amino phenyl
sulphonamide) cinnoline-3-carboxamide were found to be most
active anti-microbial agents.
KEY WORDS: Cnnoline, sulphonamide,
Von-Richter synthesis, anti-microbial activity.
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