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7. Synthesis
and Characterization of Some 5-Phenyl-1-(Acyl)-1, 2, 3, 4-Tetrazole
Popat B. Mohite1, Ramdas B.Pandhare1,Shantaram
G.Khanage1,*Vaidhun H. Bhaskar2
1MES College of Pharmacy,
Sonai,Ahmednagar,Maharashtra,India
2MP Patel College of Pharmacy,Kapadwanj, Gujrat,India.
*E-mail-mohitepb@rediffmail.com
For Correspondence: Popat B.Mohite, MES College of Pharmacy,Sonai,
Tel-Newasa,Dist-Ahmednagar, Maharashtra-414105 India,
Mob no.-09890520854, Fax No.02427 230948, E-mail-mohitepb@rediffmail.com
Abstract:
A
series of novel 5-phenyl,1-(acyl)-1,2,3,4-tetrazoles (2–10) have
been synthesized via condensation of 5-phenyl-1,2,3,4-tetrazoles
(1) with various acylating reagents. 5-phenyl-
1,2,3,4-tetrazoles was synthesized by the cycloaddition of
Benzonitrile(1) with sodium azide and ammonium chloride in
presence of Dimethylformamide as solvent and concentrated
hydrochloric acid as acidifying agent. All synthesized compounds
which were characterized to be new substituted Tetrazoles. Their
structures were determined by 1H NMR,FT-IR, mass
spectra and elemental analyses.
KEYWORDS: Tetrazoles,
Dimethylformamide, Benzonitrile.
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