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16.
Spectrophotometric Methods for the Determination of Repaglinide in
tablets Using Indigo Carmine
Mukesh Chandra Sharma* a, Smita Sharma b,
S.C.Chaturvedi c
a* School of
Pharmacy, Devi Ahilya Vishwavidyalaya, Indore (M.P) 452001, India
b Department of Chemistry Yadhunath Mahavidyalya Bhind (M.P)
477001 India
c Shri Arvindo Institute of Pharmacy Ujjain Road Indore (M.P)
453111 India
E-mail:
mukeshcsharma@yahoo.com
Abstract.
New method Developed method is based on the formation of
extractable colored complex of drug with coloring agent Indigo
Carmine. A wavelength maximum was found to be 562 nm. The
concentration range of 10-30 μg ml-1 with linear
regression of 0.9997, while the percentage recovery, LOD and LOQ
were 100.03-101.01 %, 0.15 μg ml-1 and 1.19 μg ml-1
respectively. The result of analysis have been validated
statistically and also by recovery studies. From the percentage
recovery and specificity studies it was concluded that there was
no interference of common additives during the estimation. This
proves the suitability of this method for the routine quality
control analysis of the Repaglinide in formulation.
KEYWORDS: Repaglinide, Spectrophotometric, Formulation,
Indigo Carmine
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