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3.
Antimicrobial activity and characterization of an alkaloid as a
natural ligand and Its Co (II) complex.
A. Jarrah1 , S. Ghammami1 , A.
Shafaghat1*, S. Bohlooli2 , G. Geimachi1
1Department
of Chemistry, Islamic Azad University, Ardabil Branch, Ardabil,
Iran.
2 Medical Sciences of Ardabil, Ardabil, Iran.
E-mail:
shafaghata@yahoo.com
Abstract.
Metal to ligand complex with molecular formula [Co (L)]Cl2
, (L= thebaine) of thebaine as an alkaloid and its cobalt
complex have been prepared and characterized by
elemental analysis, 1H-NMR, IR and UV-Visible
spectroscopy. The Biological activity of alkaloids is
believed to increase when they are coordinated with
transition metal ions. However, the literature on this
subject is contradictory and the outcome seems to largely
depend on the experimental conditions. The results of this
analyze indicate that the complex has a Co (II) ion
coordinated via positions 4, 5- epoxy (oxygen atom) and 6 of
the thebaine. The antimicrobial activity of this complex was
studied and the thebaine –Co (II) complex 1 showed
antibacterial activities.
KEY
WORDS:
Thebaine complex, Alkaloid, Cobalt, Antimicrobial
activity.
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