5.
Environmentally Benign Studies of Bivalent Transition Metal
Complexes of Tridentate (NNO donor) Schiff Base Ligands
S.N. Vidyarthi1, K.P. Srivastava2*, Sapna
Kumari3& Rakesh Singh1
1
Department of Chemistry, Jai Prakash University, Chapra-841301,
INDIA
2Principal, Ganga Singh College, Chapra-841301, INDIA
3R.P.College, Datiyana, Vikram, Patna, Bihar. E-mail:
kpsri@yahoo.co.in
Abstract:
A
rapid, efficient, clean and environmentally benign exclusive
synthesis of Schiff bases as new ligands has been developed
using condensation of 2-aminonicotinic acid with salicyldehyde,
5-nitrosalicyldehyde, 5-bromosalicyldehyde and 5-methoxysalicyldehyde
efficiently in a water suspension medium using acid catalyst
with excellent yields under microwaves irradiation. The results
are compared with conventional methods. All the Schiff bases
were tridentate (NNO donor) ligands that were used for
complexation with Co2+, Ni2+ and Zn2+ions. All the ecofriendly
synthesized Schiff bases and their metal complexes were
characterized by analytical and spectral methods. The
synthesized Schiff bases and their transition metal complexes
were evaluated for their in vitro antibacterial activity against
four gram-negative and two gram-positive bacterial stains by the
agar-well diffusion method. Schiff bases were found to exhibit
either no or low to moderate activity but all the complexes
exhibited varied vigorous activity against different bacteria.
Schiff bases which were inactive before complexation became
active and less active became more active upon coordination with
mentioned bivalent transition metal ions.
Keywords: Microwave
irradiation, Schiff bases, Coordination compounds, Antibacterial
activity.
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