Abstract: The study was conducted in six water bodies along the coast of Ghana namely: Pra estuary, Benya lagoon, Fosu lagoon, Nakwa lagoon, Volta estuary and Keta lagoon. The effect of contamination with five essential nutrients known to be harmful to human health when taken in quantities higher than the recommended daily intakes was examined. The results indicate that all the six aquatic ecosystems have higher levels of aluminium and bromine than the recommended daily intakes. However, calcium, copper and vanadium concentrations in the standard water bodies were lower than the recommended daily intakes. The aquatic species commonly exploited as sources of protein, namely Macrobrachium vollenhovenii, Crassostrea tulipa, Sarotherodon melanotheron and Chonophorus lateristriga living in these ecosystems had higher levels of contamination with aluminium, bromine and copper than the recommended daily intakes. Vanadium levels in S. melanotheron from Benya, Fosu and Keta lagoons as well as in Crassostrea tulipa from Nakwa lagoon was higher than the recommended daily intake of 1.8 mg/l. However, calcium concentrations in all the fin-fish and invertebrate organisms from the six aquatic habitats were significantly lower than the recommended daily intake of 1,000 mg/l. It was concluded that the high levels of essential nutrient concentrations (except calcium and, in some few cases, vanadium) could pose health threats to consumers. It is recommended to perform further studies on the other water bodies along Ghana coast of, to assess the biota contamination levels.