11.
Spectrophotometric Determination of Naproxen and Esomeprazole in a
Laboratory Mixture by Simultaneous Equation, Absorption Correction,
Absorption Ratio and Area Under Curve Methods
Neha A. Jain*, R.T.Lohiya and M.J.Umekar
S.K.B.
College of Pharmacy, New kamptee, Nagpur, Maharashtra, India.
*Corres. author:
niki_j19@yahoo.com
Abstract:
An accurate, specific and precise UV spectrophotometric method
was developed for the simultaneous determination of naproxen
(NP) and esomeprazole (EOZ) in a laboratory mixture of these two
components. The method involves area under curve (AUC) method in
the range 227-237nm and 296.5-306.5nm respectively, formation of
simultaneous equation at 232nm and 301.5nm respectively,
absorption correction method at 232nm λmax of naproxen, 239.2nm
isoabsorptive point of NP & EOZ & 301.5nm for absorption ratio
method by using methanol as a solvent. The linearity for both
naproxen and esomeprazole was in the range of 1-5 µg/ml and
4-12µg/ml respectively. The % recovery was found to be 98.23%
and 98.87% for naproxen and esomeprazole respectively indicating
proposed method is accurate and precise for simultaneous
estimation of naproxen and esomeprazole in bulk formulations.
Keywords: Naproxen, Esomeprazole, UV spectrophotometry,
Simultaneous equation method, Absorption ratio, absorption
correction method and Area under curve.
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