Abstract: During the past two decades, there has been an increasing interest in the investigation of different extracts obtained from traditional medicinal plants as potential sources of potent drugs or supplements for the management of human and animal health. The phytochemical, antioxidant and cytotoxicity of the extracts of Anchomanes difformis tuber were examined. The proximate analysis of the tuber was found to contain carbohydrates 63.64 %, protein 1.31 %, fat 1.5 %, crude fibre content 12.3 %, ash content 6.75 % and moisture content 14.5 %. The two extracts tested negative for saponins, resins, terpenoids, phenols, balsam, anthracene, anthraquinone, while the ethanol extract tested positive for alkaloids, tannins, sterols, phlobatannins and volatile oils.  The antioxidant activity LC50 of 2.64 mg/ml, 1.82 mg/ml and 0.14 mg/ml were recorded for the hexane, ethanol extracts and Vitamin C respectively. The cytotoxicity result showed that both extracts exhibited LC50 of less than 1000 mg/ml with aid of Finney computer programming.

Keywords: Anchomanes, difformis, phytochemical, antioxidant, cytotoxicity, Artemia salina