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8.
Anticancer activity of
ribose fused pyrimidine derivative by SRB assay method
Rupesh Dudhe*a,b, Pramod K Sharmab,
Virendra K Singhb, Anshu Chaudharyc, Nitin
Kumarb Prabhakar Vermad
aUttarakhand
Technical University, Dehradun- 284007, Uttarakhand, India.
bDepartment
of Pharmaceutical Technology, M.I.E.T., Meerut- 250005, Uttar
Pradesh, India.
cVishveshwarya
institute of medical science, Greater Noida- 203207, Uttar
Pradesh, India.
d
Department of Pharmaceutical Sciences, M. D. University, Rohtak-
124001 Haryana. India.
Abstract:
Pyrimidine and fused pyrimidine derivatives play
an important role in therapeutic strategies. It is known to be
most prominent structures found in nucleic acid, including
uracil, thymine, cytosine, adenine and guanine, which are
fundamental building blocks for deoxyribonucleic acid (DNA) and
ribonucleic acid (RNA). A series of 4-substituted-3,
4-dihydro-1-(tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl)-6-phenylpyrimidine-2(1H)-one
derivatives were prepared by reacting substituted benzaldehyde
with acetophenone in the presence of NaOH by Knoevenagel
reaction, Cyclization and Satos fusion. The chemical structures
were confirmed by means of FTIR (Fourier Transform Infra Red
Spectrophotometer-8400S), 1HNMR, Mass and elemental
analysis. The data of these synthesized compounds were submitted
to ACTREC (Advance Center for Treatment Research and Education
in Cancer) Mumbai, India. for the activity of compound on
cancer cell line. Among all the synthesized compounds, compound
6C gives most potent activity on comparing with a positive
control Adrimycin (Doxorubicin).
Key words:
Anti-cancer, Knoevenagel reaction, Pyrimidine.
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