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3.
NaHSO4-SiO2 as an efficient catalyst for the synthesis of some
2-arylbenzothiazole derivatives
a K. Ravi Kumar*, b G.Udaya Bhanu, b
M. R. Shiva Lingam, a B. Srinivasa Reddy
a
RA chem pharma limited, R&D division, prasanth nagar, Hyderabad
, AP, India
b Victoria college of pharmacy, Department of pharmaceutics,
Guntur, AP, India
*corresponding author: Tel: +919000443184; e-mail;
ravi.kannasani@gmail.com
Abstract:
An efficient protocol has been developed for the preparation
of a series of 2‐arylbenzothiazole derivatives from the
condensation of 2‐aminothiophenol with aromatic aldehydes in
the presence of catalytic amount of silica supported sodium
hydrogen sulphate (NaHSO4-SiO2) under
refluxing in ethanol solvent to obtained excellent yields.
This method is simple, convenient, environmental friendly,
reusable, efficient and practical.
Keywords:
NaHSO4-SiO2, 2-aminothiophenol,
benzothiazole derivatives, aldehydes, reusable catalyst.
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