International Journal of Pure and Applied Chemistry (IJPAC)

 

5. New hexadecan-2-ol and 3-hydroxymethyloctadecanoate with hepatoprotective activity and cytotoxicity activity from Grindelia camporum

 

A.M.El-Moghazy1, F.M.Darwish1*, E.S.El-Khayat2, M.O.Mohamed2, M.Wink3 and M.Z.El-Readi4

 

1 Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt.
2 Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
3 Institute of Pharmacy and Molecular Biotechnology(IPMB), University of Heidelberg,Germany.
4 Department of Biochemistry, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt.
*Correspondence: F.M.Darwish:: Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt. 
 E-mail: Fdarwish@yahoo.com

Abstract: New hexadecan-2-ol (8) and 3-hydroxymethyloctadecanoate (10), together with 14 known compounds (1-7, 9, 11-16) have been isolated from Grindelia camporum Greene var. camporum. The new compounds were characterized through spectroscopic studies including 1D (1H and 13C NMR) and 2D (COSY, HSQC and HMBC) NMR and mass spectroscopy. The known compounds (Compounds 3 and 4 are hitherto unreported from family Asteraceae) were identified by comparison of their spectral data with those reported in the literature, chemical evidence or authentic samples. The total methanolic extract and the total aqueous extract exhibited cytotoxic and hepatoprotective activities respectively. Also antimicrobial, toxicological (LD50), anti-inflammatory, antipyretic and analgesic activities of the different fractions were studied.
 

Keywords: Fatty acid derivatives, triterpenes, diterpene, flavonoid, biological activities.
 

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