5.
New hexadecan-2-ol and 3-hydroxymethyloctadecanoate with
hepatoprotective activity and cytotoxicity activity from Grindelia
camporum
A.M.El-Moghazy1, F.M.Darwish1*,
E.S.El-Khayat2, M.O.Mohamed2, M.Wink3
and M.Z.El-Readi4
1
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University,
Assiut, Egypt.
2 Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar
University, Assiut, Egypt.
3 Institute of Pharmacy and Molecular Biotechnology(IPMB),
University of Heidelberg,Germany.
4 Department of Biochemistry, Faculty of Pharmacy, Al-Azhar
University, Assiut, Egypt.
*Correspondence: F.M.Darwish:: Department of Pharmacognosy, Faculty
of Pharmacy, Assiut University, Assiut, Egypt.
E-mail:
Fdarwish@yahoo.com
Abstract:
New hexadecan-2-ol (8) and 3-hydroxymethyloctadecanoate (10),
together with 14 known compounds (1-7, 9, 11-16) have been
isolated from Grindelia camporum Greene var. camporum. The new
compounds were characterized through spectroscopic studies
including 1D (1H and 13C NMR) and 2D (COSY,
HSQC and HMBC) NMR and mass spectroscopy. The known compounds
(Compounds 3 and 4 are hitherto unreported from family
Asteraceae) were identified by comparison of their spectral data
with those reported in the literature, chemical evidence or
authentic samples. The total methanolic extract and the total
aqueous extract exhibited cytotoxic and hepatoprotective
activities respectively. Also antimicrobial, toxicological (LD50),
anti-inflammatory, antipyretic and analgesic activities of the
different fractions were studied.
Keywords: Fatty acid derivatives, triterpenes, diterpene,
flavonoid, biological activities.
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