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10- Synthesis,Tautomeric Structure and Cyclization of
Diazonium
Coupling Products of 3-(Aroylmethyl)-8-phenylpyrimido[1,2-b][1,2,4]triazine–2,6(1H)-dione
Ahmad S. Shawali*a, Thoraya A. Farghalya and
Mastoura M. Edreesb
a)Department
of Chemistry, Faculty of Science, University of Cairo, Giza, Egypt
b)
National Organization for Drug Control and Research, Giza, Egypt.
*Correspondence author: E-mail:
as_shawali@yahoo.com
Abstract
- A series of 1H-pyrazolo[3,4-e]pyrimido[1,2-b][1,2,4]triazine
derivatives 5 were prepared via dehydrative
cyclization of
3-(N-aryl-2-oxo-2-phenyl-ethanehydrazonoyl)-8-phenylpyrimido[1,2-b][1,2,4]triazine-2,6(1H)-diones
4 and their biological activity was evaluated. The
latter precursors 4 were prepared by coupling of
3-(benzoylmethyl)-8-phenyl-pyrimido[1,2-b][1,2,4]triazin-2,6(1H)-dione
3 with diazotized anilines and their tautomeric structure was
elucidated.
Keywords: Azo-hydrazone tautomerism,
2,3-Diamino-6-phenylpyrimidin-4(3H)-one;
1H-Pyrazolo[3,4-e]Pyrimido[1,2-b][1,2,4]triazine
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