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06- Syntheses and Characterisation of Four Trinuclear
Complexes of The Form: [{Trans-Ptcl(NH3)2}2m-{Trans-Pd(NH3)2(H2N(CH2)Nnh2)2]Cl4 Where
N = 4 to 7
Fazlul Huq*1,
Hassan Daghriri1, Jun Qing Yu1, Philip Beale2
and Keith Fisher3
1School
of Biomedical Sciences, Cumberland Campus, C42, The University of
Sydney, East Street, PO Box 170, Lidcombe, NSW 1825,
Australia.
2RPAH,
Missenden Road, Camperdown NSW,
Australia
3School
of Chemistry, F11,
University of
Sydney, NSW 2006,
Australia.
*Correspondences auhor: Dr. Fazlul Huq, School of Biomedical Sciences,
Faculty of Health Sciences, C42, The University of Sydney,
PO Box 170, Lidcombe, NSW 1825, Australia.
Tel.: +61 2 9351 9522 Fax: +61 2 9351
9520
E-mail :
f.huq@fhs.usyd.edu.au
Abstract:
Four tumour active trinuclear complexes: DH4Cl: [{trans-PtCl(NH3)2}2m-{trans-Pd(NH3)2(H2N(CH2)4NH2)2]Cl4,DH5Cl:
[{trans-PtCl(NH3)2}2m-{trans-Pd(NH3)2(H2N(CH2)5NH2)2]Cl4,
DH6Cl: [{trans-PtCl(NH3)2}2m-{trans-Pd(NH3)2(H2N(CH2)6NH2)2]Cl4
and DH7Cl: [{trans-PtCl(NH3)2}2m-{trans-Pd(NH3)2-(H2N(CH2)7NH2)2]Cl4
have prepared and characterised based on elemental analyses, IR,
Raman, mass and
1H
NMR spectral measurements. The synthesis has been carried out using a
step-up method branching out from the central palladium unit. Some of
the compounds are found to be significantly more active than cisplatin
against a number of ovary cancer cell lines. More detailed studies on
the activities of the compounds, cell up take and DNA binding is
reported in a separate paper.
Keywords:
Cisplatin; BBR3464; Pt/Pd complex; anticancer drugs;
1,6-diaminohexane; cell culture
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