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08- Synthesis of N-substituted
analogues of Quindoline and their biological properties.
Y.
Opoku-Boahen1,2,* and J. Mann1,3
1.Department
of Chemistry,
University
of Reading, Whiteknights Park, Reading, RG6 2AD. England.
2.Department
of Chemistry,
School
of Physical Sciences,
University of Cape Coast, Cape Coast, Ghana.
3.McClay
Chair of Biological Chemistry, School of Chemistry, Queen’s University
of Belfast, David Keir Building, Belfast, BT9 5AG, Northern Ireland.
Correseponding author: Department of Chemistry, University of
Reading, Whiteknights Park, Reading, RG6 2AD. England. E-mail:
yawoboahen@yahoo.com
Abstract:
Two new analogues of quindoline,
10-(Benzenesulphonyl)indolo[3,2-b]quinoline and
10-(Dimethylethylaminoethyl) indolo[3,2-b]quinoline have been
synthesized. The compounds were evaluated against the test bacteria
Escherichia. coli and Bacillus subtilis by the Agar
Diffusion assay. Both compounds showed modest activity as determined
by the diameter of the zones of inhibition.
Key words:
Cryptolepis sanguinolenta,
Quindoline, cytotoxocity, biological properties, agar diffusion assay.
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