Abstract: Recently a series of 1-methylene-4-(5-(4-(phenylamino)phenyl)-1,3,4-thiadiazol-2-yl)thiosemicarbazide derivatives were synthesized and their pharmacologically evaluated for antimicrobial activities. The purpose of this study was to evaluate the potency of the title compounds on bacterial and fungal activities by varying the substituted in the 1-methylene-4-(5-(4-(phenylamino)phenyl)-1,3,4-thiadiazol-2-yl)thiosemicarbazide derivatives. All compounds of this series showed promising antimicrobial activities. It was found that some of these compounds possess marked antifungal and antibacterial properties comparable in efficiency to the reference drug Flukanazole and Ciprofloxacin respectively. In present study the structures of compounds were confirmed by UV, IR, 1H NMR.
 

Keywords:1-methylene-4-(5-(4-(phenylamino)phenyl)-1,3,4-thiadiazol-2-yl) thiosemicarbazide derivatives; antibacterial agents; antifungal agents; S. aureus; B. subtilis; E. coli; K. pneumoniae; C. albican; A. niger and UV, IR, 1H NMR spectroscopy.