Abstract:
The
synthesis and pharmacological activity of a new series of non
peptide angiotensin (A-II) receptor antagonist has been
prepared. This
[(2-substituted-5-nitro-benzoimidazol-1-ylmethyl)-biphenyl-2-carboxylic
acid differ from the previously reported and related compounds
in that they produce a potent hypertensive effect upon oral
administration. substituent at 5 position (nitro ) were
synthesized and tested for antihypertensive activity in An
insertion-cyclization strategy was involved during synthetic
path sequences. Structures of all the synthesized compounds have
been corroborated on the basis of elemental IR, 1H
NMR, 13C NMR and Mss spectro-analytical data. It also
reports the in antihypertensive activity studies performed on
synthesized compounds against a representative panel of losratan
and Telmisartan, inhibition of AII-induced increase in blood
pressure, pithed rats.
Keywords: 5-nitro -Benzimidazole Derivative, angiotensin II,
Anti-hypertensive agent